PROGNOSTIC VALUE OF MANNOSE BINDING LECTIN AND VITAMIN D IN DENGUE: STUDY FROM A TERTIARY CARE CENTRE FROM SOUTHERN INDIA

• THRILOK CHANDER BINGI,*  
• SABEEHA NAAZ,  
• ANSARUDDIN ZOHEB MOHD

Abstract

BACKGROUND: Dengue disease severity is related to dysregulated immune response. Mannose Binding Lectin (MBL) and Vitamin D alter innate and adaptive immune responses to the virus. Hence, we wanted to look at the prognostic value of these early serum biomarkers for reducing mortality and morbidity. OBJECTIVES • AIM: To determine Serum mannose-binding lectin and vitamin D levels in patients diagnosed with Dengue. • OBJECTIVES: To correlate serum MBL and vitamin D levels with Dengue severity. METHODOLOGY: Observational Study Including 100 dengue-positive patients. RESULTS: The Study Patients were divided into three groups, dengue without warning signs (group 1), dengue with warning signs (group 2), and severe dengue (group 3). MBL levels have significant P values between Group 1 and Group 3 (p=0.002) and Group 2 and Group 3 (p=0.005). Vitamin- D levels have a significant p-value between group 1 and group 2 (p=0.008) group 1 and group 3 (p=0.000) group 2 and 3 (p=0.000). Hence lower levels of MBL are associated with severe dengue and patients with low levels of vitamin D had less severe dengue. CONCLUSIONS: This study highlights the immunomodulator role of MBL and Vitamin D in shifting immune responses from Th-1 to Th-2 resulting in dengue severity. The role of Vitamin D is always thought to be protective but it may act as a double-edged sword. This study also opens new doors of therapeutics in treating dengue infection.

Keywords

DENGUE,MBL,VITAMIN D ,COMPLEMENT PATHWAY