Determination of vancomycin, linezolid and daptomycin resistance among Eenterococcus isolates from a tertiary care hospital

---

Original Article

Author Details : Jaswinder Singh Gill*

Volume : 7, Issue : 2, Year : 2020

Article Page : 142-145

https://doi.org/10.18231/j.ijmr.2020.026

Suggest article by email

Get Permission

---

Abstract

Introduction: The clinical importance of the genus Enterococcus species relates to its intrinsic antibiotic
resistance. Synergistic activity of penicillin and aminoglycosides against Enterococcusis preferred
treatment. However, Infectious Diseases Society of America (IDSA) recommends usage of linezolid and
daptomycin against emerging vancomycin resistant Enterococcus(VRE) isolates. In this study, we sought
to measure the prevalence of vancomycin, linezolid and daptomycin resistance in Enterococcus clinical
isolates from patients in a tertiary hospital of Western Maharashtra.
Materials and Methods: A total of 363 clinical isolates of Enterococcusspecies isolated from different
clinical samples over the last three years and three months study period were analyzed for antibiotic
susceptibility pattern against vancomycin, linezolid and daptomycin.
Results: Study demonstrated low prevalence of vancomycin (4.95%) and linezolid resistance (1.10%)
among Enterococcus clinical isolates. Combined resistance to vancomycin and linezolid was also noted in
few isolates. No daptomycin resistance was detected in this study, however in vitro daptomycin susceptible
and vancomycin heteroresistance isolates may not respond to daptomycin monotherapy.
Conclusion: Our study, demonstrated relatively low prevalence of vancomycin and linezolid resistance, but
emergence of combined newer drug resistance in Enterococcus species is cause of concern and reiterates
the importance of importance of judicious use of antibiotics.

Keywords: VRE, Linezolid, Daptomycin, E test.

How to cite : Gill J S , Determination of vancomycin, linezolid and daptomycin resistance among Eenterococcus isolates from a tertiary care hospital. Indian J Microbiol Res 2020;7(2):142-145

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.