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Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh
- Author Details:
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Ranjana Hawaldar
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Sadhna Sodani
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Hemlata Bhilware
Introduction: Typhoid fever or enteric fever, is an endemic disease in many developing countries specially India and the Indian Subcontinent. In the past decade, resistance of Salmonella to multiple drugs is on the rise specially resistant to ampicillin, chloramphenicol and cotrimoxazole. This resistant pattern has resulted in use of Fluoroquinolones and third generation Cephalosporins as first line drugs.)The present study was under taken to study the antibiotic susceptibility pattern of S.typhi isolated from blood cultures in our microbiology laboratory.
Materials and Methods: 766 patients suspected of having typhoid fever of different age groups and sex visiting our Microbiology department for blood culture were included in the study from January 2015 to December 2015. Gram negative non lactose fermenting colonies were subjected to identification and antibiotic susceptibility testing in Vitek II (Biomerieux) according to CLSI guidelines.
Results: Out of 766 blood cultures, 32 cases of S.typhi were isolated. 561 cultures were sterile and 73 showed growth of other bacteria. Colistin, Cefuroxime, Imipenem, Meropenem showed 100% sensitivity. Piperacillin/Tazobactam, Tigecyline. Cefoperazone/Sulbactam were sensitive in 93.75% isolates. Amoxicillin/Clavulanic Acid (90.62%), Ceftazidime(87.5%), Trimethoprim/Sulfamethoxazole (87.5%), Ticarcillin(84.37%), Ampicillin (81.25%),Cefepime(78.12%), Cefalotin(75%), Amoxycillin(65.62%), Cefixime(59.37%). Cefoxitin(43.75%), Amikacin(31.25%), Gentamicin(6.75%), Ciprofloxacin was found to be resistant in all 32 cases(100%).
Conclusion: There has been a reemergence in the sensitivity of Salmonella Typhi to Ampicillin, Ceftazidime, Cefuroxime Ceftriaxone, Cefoperazone/Sulbactum Cefipime and Amoxyclav and 100% resistance to Ciprofloxaxin and to Amikacin & Gentamycin. Cefuroxime, Ceftriaxone, Cefoperazone/Sulbactum seem to be good therapeutic options is our setting atpresent.
Key words: Antibiotic susceptibility, Salmonella Typhi, Typhoid fever
References
- Rockhill RC, Lesmana M, Moechtar MA, Sutomo A. Detection of Salmonella Ci, D and Vi antigens by Coagglutination in blood culture from patients with Ranjana Hawaldar et al. Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone…. Indian J Microbiol Res 2016;3(1):31-36 36 Salmonella infections. Southeast Asian J Trop Med Publ HLTH 1980; 11: 441-445.
- Saha SK, Amin, Hanif M, Islam M & Khan WA. Interpretation of the Widal test in the diagnosis of typhoid fever in Bangladeshi children. Annals of Tropical Paediatrics 1996; 16: 75-78.
- Mehta PJ, Hakim A, Kamath S. The changing faces of salmonellosis. J Assoc Physicians India 1992:40;713.
- White NJ, Parry CM. The treatment of typhoid fever. Current opinion Infect Disease 1996; 9: 298-302.
- Kanungo S, Dutta S, Sur D. Epidemiology of typhoid and paratyphoid fever in India. J Infect Dev Ctries 2008;2:454-
- Capoor MR, Nair D, Hasan AS, Aggarwal P, Gupta B. Typhoid fever: Narrowing therapeutic options in India. Southeast Asian J Trop Med Public Health 2006;37:1170-4.
- Lovely Akter , Munir Hassan and Zakaria Ahmed: Present Status And Antibiotic Sensitivity Pattern of Salmonella Typhi And S. Paratyphi In Different Age Group Hospitalized Patients In Dhaka City, Bangladesh: IOSR Journal of Pharmacy and Biological Sciences Volume 4, Issue 3 (Nov. – Dec. 2012), PP 27-30.
- Krishnan P, Stalin M, and Balasubramanian S (2009) Changing trends in antimicrobial resistance of Salmonella enterica serovar typhi and salmonella enterica serovar paratyphi a in Chennai. Indian J Pathol Microbiol, 52:505-8.
- Bulbul Hasan, Sabera Gul Nahar, Laila Akter , Ahmed Abu Saleh, Antimicrobial sensitivity pattern of Salmonella typhi isolated from blood culture in a referral hospital : Bangladesh J Med Microbiol 2011; 05 (01): 16-20 .
- L Singhal, PK Gupta, P Kale, V Gautam, P Ray Trends in antimicrobial susceptibility of Salmonella Typhi from North India (2001-2012) Indian Journal of Medical microbiology 2014 , Volume: 32| Issue : 2 | Page : 149-152.
- N. U. Adabara, , B. U. Ezugwu, A. Momojimoh, A. Madzu, Z. Hashiimu, and D. DamisaThe Prevalence and Antibiotic Susceptibility Pattern of Salmonella typhi among Patients Attending a Military Hospital in Minna, Nigeria:Adv Prev Med. 2012; 2012: 875419.
- Crump JA, Medalla FM, Joyce KW, Krueger AL, Hoekstra RM, Whichard JM, et al. Antimicrobial resistance among invasive nontyphoidal Salmonella enterica isolates in the United States: National Antimicrobial Resistance Monitoring System, 1996 to 2007. Antimicrob Agents Chemother. 2011 Mar. 55(3):1148-54.
How to Cite This Article
Vancouver
Hawaldar R, Sodani S, Bhilware H. Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh [Internet]. Indian J Microbiol Res. 2016 [cited 2025 Oct 15];3(1):31-36. Available from: https://doi.org/
APA
Hawaldar, R., Sodani, S., Bhilware, H. (2016). Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh. Indian J Microbiol Res, 3(1), 31-36. https://doi.org/
MLA
Hawaldar, Ranjana, Sodani, Sadhna, Bhilware, Hemlata. "Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh." Indian J Microbiol Res, vol. 3, no. 1, 2016, pp. 31-36. https://doi.org/
Chicago
Hawaldar, R., Sodani, S., Bhilware, H.. "Antibiotic Sensitivity Pattern of Salmonella Typhi in a Stand Alone Lab in Central Madhya Pradesh." Indian J Microbiol Res 3, no. 1 (2016): 31-36. https://doi.org/