MUTATION STUDIES ON STREPTOMYCES FOR AMPHOTERICIN B YIELD IMPROVEMENT

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Original Article

Author Details : Anitha Upadhyaya, Nagasatya A, Thajuddin N, Paneerselvam A, Upadhyaya Giridhara

Volume : 1, Issue : 1, Year : 2014

Article Page : 56-59

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Abstract

Four Streptomyces strains isolated from the soil of Western Ghats of India producing Amphotericin B were subjected to random mutagenesis by UV irradiations for yield improvement. The mutants were then screened for their Amphotericin B concentrations and their antifungal activity by agar well diffusion method. Two mutants demonstrated 13% and 16% higher concentration than the isolated strains respectively. Thus mutation can be a very useful tool to minimize production cost with the same benefits.

Keywords: Amphotericin B, UV mutation, Streptomyces, strain improvement

How to cite : Upadhyaya A, Nagasatya A, Thajuddin N, Paneerselvam A, Giridhara U, MUTATION STUDIES ON STREPTOMYCES FOR AMPHOTERICIN B YIELD IMPROVEMENT. Indian J Microbiol Res 2014;1(1):56-59

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