New insights: mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) infection in southern Indian region

---

Original Article

Author Details : Umme Hani, Masood Ahmed Tahashildar*, Anil Kumar

Volume : 11, Issue : 2, Year : 2024

Article Page : 103-106

https://doi.org/10.18231/j.ijmr.2024.019

Suggest article by email

Get Permission

---

Abstract

Background:  Methicillin-resistant Staphylococcus aureus (MRSA) remains to be the most concerned pathogen with enhanced multi-drug resistance in clinical set-ups. With an immediate need to control MRSA infection, there is a steep rise in the use of mupirocin as a decolonization regime.
infection, there is a steep rise in the use of mupirocin as a decolonization regime.
Materials and Methods:  A total of 65 MRSA samples were analysed in the present study. Staphylococcus infection identified by standard conventional phenotypic methods. The antibiotic susceptibility pattern of mupirocin (5 ?g/ml) was found using Kirby Bauer’s disc diffusion method and the minimum inhibitory concentration (MIC) determined using MIC E-test strips of mupirocin.
Results:  All the bacterial strains presented with MIC value less than 4 ?g/ml, 23 isolates falls in the range of 0.05 ?g/ml and 0.19 ?g/ml, 12 strains MIC ranged between 0.125 and 0.640 ?g/ml. However, five MRSA isolates showed no zone against mupirocin E-strip.
Conclusions:  In present study, 92% of isolates were sensitive to mupirocin, this gives hope that mupirocin can be promising in the elimination of MRSA strains, a major concern in clinical practice. Also, the use of 5µg mupirocin discs is economical as compared to mupirocin E-strips, mupirocin discs can be used in a low resourceful clinical setups. However, our study revealed no difference in sensitivity for both the E-strip and disc method.
 

Keywords: Antimicrobial resistance, Methicillin- resistant Staphylococcus aureus, Mupirocin, Antimicrobials, Minimum inhibitory concentration.

How to cite : Hani U, Tahashildar M A, Kumar A, New insights: mupirocin resistance among methicillin-resistant Staphylococcus aureus (MRSA) infection in southern Indian region. Indian J Microbiol Res 2024;11(2):103-106

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.