Study of the antibiotic sensitivity pattern of Pseudomonas aeruginosa and its mechanism of resistance


Original Article

Author Details : Sadhna Sodani, Ranjana Hawaldar

Volume : 3, Issue : 4, Year : 2016

Article Page : 472-478


Suggest article by email

Get Permission

Abstract

Introduction: The multidrug resistant nature of P. aeruginosa is a major cause of morbidity in immunocompromised patients. The mechanisms which play a role in causing multidrug resistance of P.aeruginosa includes lower outer membrane permeability, increased expression of efflux pumps, presence of Amp C Beta lactamase enzyme. The present retrospective study aims to analyse the antibiotic sensitivity pattern of P.aeruginosa in our clinical setting in various clinical specimens and to study the various mechanisms playing a role in resistance to antibiotics.
Materials and methods: The retrospective study included all the Psedomonas aeruginosa isolates from clinical specimens received in our microbiology department between June 2015 to June 2016. The specimens included pus, aural swab, conjunctival swab, blood, urine and endotracheal tube. A total of 40 cases were included in the study.
Results: highest sensitivity was observed for amikacin(65%), Piperacillin/ tazobactum(52.5%),Gentamycin(47.5%) Highest resistance (77.5%) was to Trimethoprim/ sulphamethaxazole, 62.5% to nalidixic acid, 57.5% cases had resistance to quinolones. Impermeability to carbapenems accounted for 42.5% cases, followed by carbapenamase(metallo-oxa) resistance mechanism in 37.5%.
Conclusion: Growing resistance to commonly used antibiotics is a major concern to clinicians as several complex mechanisms are involved in the multi-drug resistance   nature of P.aeruginosa. Careful use of antibiotics, culture and sensitivity testing and prudent selection of drugs and effective infection control measures would help the clinicians in planning and executing effective treatment thus limiting the emergence of multidrug resistant strains of Pseudomonas aeruginosa.


Keywords:
P. aeruginosa, Resistance mechanism, AAC, ANT, Carbapenemase, AmpC


How to cite : Sodani S, Hawaldar R, Study of the antibiotic sensitivity pattern of Pseudomonas aeruginosa and its mechanism of resistance. Indian J Microbiol Res 2016;3(4):472-478


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







View Article

PDF File  


Copyright permission

Get article permission for commercial use

Downlaod

PDF File    






Article Access statistics

Viewed: 1574

PDF Downloaded: 509