Antibiotic susceptibility pattern of bacterial uropathogens isolated from patients at a tertiary care hospital

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Original Article

Author Details : Vijetha Sajjanar, D. E. Premlatha, Halesh L. H.

Volume : 4, Issue : 3, Year : 2017

Article Page : 341-345

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Abstract

Background: Urinary tract infection (UTI) is one of the most common infections in both outpatients and hospitalized patients. The increasing prevalence of antimicrobial resistance is a major health problem & is associated with high morbidity & mortality.
Objectives of the study: 1. To analyse the antimicrobial resistance pattern of uropathogen during a period of 6 month in patients of UTI. 2. To know the prevalence of uropathogens.
Materials and Method: A prospective study was conducted on urine specimens suspected to be having urinary tract infection between July 2016 and December 2016 received at Department of Microbiology, SIMS Shimoga. Fresh midstream urine samples were aseptically collected in sterile containers and plated on Blood agar & MacConkey agar plates using a standard loop technique & the growth was processed by standard bacteriological technique. Antimicrobial sensitivity testing was done using Kirby-Bauer methods on Mueller-Hinton agar. Results were interpreted as per the CLSI guidelines.
Result: Out of 510 samples 250 samples showed significant bacteriuria. Most common uropathogen isolated was Escherichia coli 61. 6%(154/250) followed by Staphylococcus aureus 19. 2%(48/250), Enterococcus species 10%(25/250), Klebsiella species 3. 2%(8/250), Pseudomonas species 1. 2%(3/250), CONS 0. 8%(2/250). Gram negative organisms were highly sensitive to Fosfomycin, Nitrofurantoin, Imipenam and highly resistant to Norfloxacin, Ciprofloxacin, Levofloxacin. Gram positive organisms were highly sensitive to Linezolid, Vancomycin, Fosfomycin, Nitrofurantoin and least sensitive to Norfloxacin, Ciprofloxacin, Amoxyclavulanic acid.
Conclusion: This study showed that high resistance was observed for commonly used antibiotics. Fosfomycin and Nitrofurantoin were the most sensitive drug for gram negative organisms mainly E. coli which is the most common uropathogen isolated.

Keywords: Fosfomycin, Nitrofurantoin, Antibiotic susceptibility, UTI

How to cite : Sajjanar V, Premlatha D E, Halesh L. H., Antibiotic susceptibility pattern of bacterial uropathogens isolated from patients at a tertiary care hospital. Indian J Microbiol Res 2017;4(3):341-345

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