Serological and haematological profile for early diagnosis of dengue infection in tertiary care hospital

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Original Article

Author Details : Patel Bhavikakumari C, Patel Disha A, Vegad Mahendra M

Volume : 5, Issue : 3, Year : 2018

Article Page : 358-363

https://doi.org/10.18231/2394-5478.2018.0075

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Abstract

Context: Dengue is a major public-health concern throughout tropical and subtropical regions of the world including India. All four serotypes of the dengue can produce wide range of the symptoms from mild clinical diseases to sever diseases. Dengue haemorrhagic fever and dengue shock syndrome may occur in secondary dengue infection with serotype other than primary infection. Early diagnosis is required for proper management of this disease and to reduce mortality.
Aim and Objectives: Present study was carried out to know prevalence of dengue in Gujarat, its epidemiological status and to co-relate the serological and haematological data for early diagnosis of dengue infection.
Materials and Methods: A retrospective study was carried out over a period of one year from January 2016 to December 2016. A total of 12,413 samples having signs and symptoms of dengue fever were processed for NS 1 Ag detection and IgM Ab detection test by ELISA according to their duration of illness. Laboratory tests of dengue positive parameters and its haematological profile were co-related.
Results: A total of 1430 samples (11.52%) were positive for dengue. Males in the age group of 16yrs to 30 yrs were predominantly affected. Monsoon and post-monsoon is a most favourable season for dengue transmission. Thrombocytopenia was more consistently associated whenever IgM was detected compared to NS1 detection.
Conclusions: Early recognition and diagnosis are important for favourable outcome. NS 1 Ag detection test by ELISA can give positive results from the 1^st day of illness. Haematological profile acts as indicators for provisional and early diagnosis of dengue.

 Keywords: IgM antibody, NS1 antigen, Thrombocytopenia.

How to cite : Patel Bhavikakumari C, Patel Disha A, Vegad Mahendra M, Serological and haematological profile for early diagnosis of dengue infection in tertiary care hospital. Indian J Microbiol Res 2018;5(3):358-363

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