Analysis of rheumatoid factor and anti-cyclic citrullinated peptide in individuals with rheumatalogical disorders attending a tertiary care hospital

---

Original Article

Author Details : Meenakshi Subramanian, Ananthakrishnan Parthasarathy*

Volume : 6, Issue : 2, Year : 2019

Article Page : 123-125

https://doi.org/10.18231/j.ijmr.2019.026

Suggest article by email

Get Permission

---

Abstract

Introduction: Rheumatoid factor (RF) has been routinely used as a diagnostic test for rheumatoid arthritis (RA). RA should be diagnosed early to prevent joint injury before the damages become inevitable. Several new laboratory tests have also been used, the commonest of them being detection of antibodies to cyclic citrullinated peptides (anti-CCP or ACPA). For the diagnosis of individuals with rheumatoid arthritis and also for prognosis these two tests are universally performed. Antibodies produced against cyclic citrullinated peptide (ACPA) have a higher specificity with almost equal sensitivity when compared to Rheumatoid Factor. Hence we proceeded to analyse these two parameters’ in our Immunology laboratory.
Aim: To analyse presence of Rheumatoid factor and ACPA in individuals with Rheumatalogical disorders.
Materials and Methods: RF was tested qualitatively by using latex agglutination. Anti-CCP was tested using mono specific ELISA kit. Our study is a retrospective observational one, performed on analysis of the reports of the samples received and tested in the Immunology laboratory of a tertiary care hospital. 331 samples referred for testing both RF and ACPA during October 2018 to December 2018 were considered to analyse the correlation.
Results: Out of 331 samples tested “18.1% of them were both RF and Anti-CCP positive, 9.3% were only Anti-CCP positive and RF negative, 5.4% were only RF positive and Anti-CCP negative and 67% were negative for both”.
Conclusion: Anti-CCP is better than RF in terms of veracity of the diagnosis, and when both these are combined the diagnostic accuracy of RA is increased.

Keywords: Rhematological disorders, Rheumatoid factor, Anti-CCP.

How to cite : Subramanian M, Parthasarathy A, Analysis of rheumatoid factor and anti-cyclic citrullinated peptide in individuals with rheumatalogical disorders attending a tertiary care hospital. Indian J Microbiol Res 2019;6(2):123-125

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.