Pefloxacin susceptibility as a surrogate test to detect ciprofloxacin-resistance in typhoidal Salmonella

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Author Details : Arunava Kali*, Pravin M. V Charles, Sreenivasan Srirangaraj, K S Seetha

Volume : 6, Issue : 3, Year : 2019

Article Page : 198-201

https://doi.org/10.18231/j.ijmr.2019.044

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Abstract

Introduction: Quinolones have been widely prescribed antibiotics worldwide for treating enteric fever. Emergence of resistance to quinolones has limited its therapeutic reliability. Low-level quinolone resistance frequently escapes detection by routine disc diffusion method of antibiotic susceptibility testing and results in treatment failure. Currently, pefloxacin disc diffusion test has been advocated as a surrogate for to differentiate ciprofloxacin -resistant Salmonella strains.
Objective: To determine effectiveness of pefloxacin disc as marker for ciprofloxacin resistance. Materials and Methods: A total of 14 S.enterica serovar Typhi and 4 S. enterica serovar Paratyphi A were tested by E-test for ciprofloxacin and disc diffusion test for nalidixic acid, ciprofloxacin and pefloxacin.
Results: All 18 of our isolates had resistance to nalidixic acid and pefloxacin. Ciprofloxacin E-test detected 16 intermediate and two resistant strains, while 14 intermediate and four resistant strains were found by disc diffusion test.
Conclusions: Ciprofloxacin non-susceptibility was common in typhoidal Salmonella isolates in our hospital. Susceptibility of nalidixic acid and pefloxacin by disc diffusion correctly revealed isolates which had increased ciprofloxacin minimum inhibitory concentration (MIC).

Keywords: Ventilator associated pneumonia: An enduring hitch in intensive care units!! A study from a tertiary care center

How to cite : Kali A, Charles P M V, Srirangaraj S, Seetha K S, Pefloxacin susceptibility as a surrogate test to detect ciprofloxacin-resistance in typhoidal Salmonella. Indian J Microbiol Res 2019;6(3):198-201

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