Indian Journal of Microbiology Research

Official Publication of Innovative Education and Scientific Research Foundation


Volume 12, Issue 2, Year 2025
Editorial
Advancing the fight against infections and antimicrobial resistance: Need for multidisciplinary translational research
Author details: Anand Bhimaray Janagond
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Review Article
Exploring application & recent advances of response surface methodology driven approach in drug design and nanotechnology
Author details: Aradhana Panigrahi, Bikash Ranjan Jena, Surya Kanta Swain, Himansu Bhusan Samal, Pratap Kumar Patra
The response surface methodology (RSM) continues to gain better importance in the current scenario in pharmaceutical analytical/formulation R & D, and healthcare industries including nanotechnology for its statistical implementation using diverse designs. The present review signifies the different t....
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From pasture to plate: Understanding antibiotic challenges in Indian livestock
Author details: Sanla K Baiju, Isha Yadava, Mahalakshmi Suriyanarayanan, G Srimathy, Varnikaa Muthuswamy, Ram Kumar Anandan, Priya Swaminathan
Farm animals in India are increasingly vulnerable to antibiotic-resistant pathogens, primarily due to the routine incorporation of antibiotics into their feed. Research indicates that the excessive antibiotic use, especially in the dairy, beef cattle, poultry, and pig sectors, has led to the emergen....
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Adamantane as the potential candidate for conjugation along with natural compounds as a potential drug for Sars-CoV-2
Author details: Amar Prakash Garg, Rahul Dev Ambedkar
We need to develop antiviral drugs against Sars-CoV-2 main protease (Mpro) because it is essential for viral replication. The Mpro enzyme has separate catalytic and dimerisation domains and operates as a homodimer. Being peptidic in nature, Cys145 and His41, two catalytic residues, are essential for....
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Original Article
Uncovering trends in hand hygiene compliance: A multi-stratification analysis from a tertiary care centre
Author details: Sarumathi Dhandapani, Benedict Vinothini A, Stessy Ann Punnen, Bharathikumar S, Ketan Priyadarshi, Apurba S Sastry
Background: Hand hygiene [HH] is the single most, least expensive preventive measure of HAI emphasized by World Health Organisation [WHO] towards patient safety, which is neglected many a time due to lack of awareness, knowledge and resources. Improving HH compliance and monitoring the adherence rat....
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Comparison of colistin susceptibility testing by VITEK 2 compact automated system and broth microdilution method for gram-negative isolates in a tertiary care hospital
Author details: Kejal Patel, Bhavin Kalidas Prajapati, Nasiruddin M Shaikh, Hiral J Shah, Jayshri Pethani, Rashidabanu ShaikhSipai
Background: The increasing global concern of colistin resistance, especially among multidrug-resistant bacteria, highlights the urgent need for enhanced surveillance. This study compared the VITEK 2 compact automated system with in-house broth microdilution (BMD) for Gram-negative isolates, assessin....
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Evaluating the predictive value of screening and confirmatory tests for asymptomatic bacteriuria in pregnant women attending a tertiary care hospital in Mehsana, North Gujarat
Author details: Payal Raval, Saakshi Shah, Komal Patel, Purav G Patel
Purpose: Asymptomatic bacteriuria (ASB) is a significant health concern among pregnant women, necessitating regular screening during all three trimesters of pregnancy. Diagnosis of ASB can be made through microscopy, urine culture, and rapid biochemical screening tests. Methodology: In this cross-s....
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Changing trends in candidemia: A four-year prospective study at a rural tertiary care hospital
Author details: Nidhi Mihirkumar Bhalodia, Som Lakhani, Mihirkumar J Bhalodia, Tanuja Javadekar, Sucheta Lakhani
Background: Candida spp. are opportunistic fungal pathogens causing invasive bloodstream infection among immunocompromised and hospitalised patients. Though Candida albicans is the most common causative species, the incidence of non-albicans species like Candida glabrata, Candida parapsilosis, Candi....
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Occurrence of BlaVIM in carbapenem resistant isolates of Klebsiella pneumoniae in a tertiary care hospital
Author details: Remya P A, Ami Chandrakant Patel, Jeswin Chandrasekhar
Background: Klebsiella pneumoniae, causes a wide range of infections in humans such as pneumonia, soft tissue infections, septicaemia, and urinary tract infections. The rise of multidrug resistant Klebsiella pneumoniae has alarming implications for public health, drastically limiting the treatment o....
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Molecular identification of SCCmec lineages in methicillin resistant Staphylococcus aureus from a tertiary care hospital
Author details: Ambica Anilkumar, Basavaraj C Metri, Jyothi P
Aim and Objective: The aim of this study is to evaluate and analyses the mecA gene and its lineages in methicillin resistant Staphylococcus aureus isolates from tertiary care hospital. Material and Methods: This is a cross-sectional molecular study conducted at tertiary care hospital Vijayapur. A t....
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Molecular detection of virulence genes from carbapenem-resistant biofilm-forming Acinetobacter baumannii isolated from a tertiary care multispecialty hospital in Pune, India
Author details: Amitesh Datta, Nageswari Gandham, Chanda R Vyawahare
Background: Acinetobacter baumannii (A. baumannii) has globally emerged as an important pathogen in hospital-acquired infections. Bacterial pathogenesis is associated with numerous virulence factors, such as colonization, invasion, biofilm formation, antimicrobial resistance, etc. The study investig....
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Analysing centrality measures for key node identification in candida glabrata protein networks
Author details: Sumathi M, Manimekalai S
Background: Candida glabrata is an opportunistic fungal pathogen increasingly associated with bloodstream infections in immunocompromised patients. Unlike Candida albicans, it lacks filamentation and demonstrates intrinsic resistance to azole antifungals, complicating treatment strategies. Understan....
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Cultivation of malarial parasites: Conceptualising one of the method of diagnosis of malaria
Author details: Sucheta Lakhani, Jitendra Lakhani, Shubham Darda
Background: Malaria is one of the diseases where successful diagnosis can lead to successful treatment and would be able to save lives. Cultivation of malarial parasite in a laboratory can aid to diagnosis and research. Materials and Methods: We are sharing experience of cultivation of malarial pa....
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Comparison of oxidative stress and viral load in HIV infected individuals with and without antiretroviral therapy
Author details: Kiran Kumar M. G, Sivasubramaniyan G, Sribal Selvarajan, Sundaravalli Pandi
Background: This study investigates the relationship between oxidative stress and viral load in HIV-infected individuals undergoing antiretroviral therapy (ART) compared to those not receiving ART. Oxidative stress, characterised by an imbalance between the production of reactive oxygen species (ROS....
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Dengue and Chikungunya co-infection: A dual arbovirus serosurvey in an industrial hub of southern West Bengal
Author details: Longjam Langamba Angom, Dipmala Das, Mousumi Paul
Background: Arthropod-borne fevers, particularly Dengue and Chikungunya, pose significant health challenges across India. While research on these illnesses is extensive in many regions, data on simultaneous infections is scarce, especially in eastern India. This study investigates the occurrence of....
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Human papillomavirus (HPV 16, 18 & 45) co-infection and patho-demographic determinants of cervical carcinoma in north Karnataka
Author details: H Ashwini, Praveen R Shahapur, Ashalata A Mallapur, Anand Bhimaray Janagon, Suresh Ullagaddi, R Manjula
Background: Cervical cancer continues to be a major contributor to cancer-related mortality among women, especially in low- and middle-income nations. A persistent infection with high-risk types of human papillomavirus (HPV) is widely recognized as the primary cause of cervical malignancy. Given tha....
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Incidence of ventilator associated pneumonia and effectiveness of ventilator bundle care in adult intensive care unit of a tertiary care hospital
Author details: Rachana Patel, Ria Jayeshkumar Kotecha, Trupti Jansari, Biswaranjan Mohanty, Bhumi Mistry, Mohammad Shoaib Shakiluddin Saiyad, Bhavin Patel
Aim and Objective: Determining ventilator associated pneumonia (VAP) rate in adult intensive care unit patients, and the effectiveness of ventilator bundle care were the objectives of this study. Materials and Methods: Adult patients admitted (18 years- 65 Years) to the Medical ICU of Dhiraj hospit....
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Vancomycin and linezolid creeping minimum inhibitory concentrations in clinical isolates of MRSA: Prelude to overt resistance
Author details: Sandhya Bhat, Desdemona Rasitha, Ravichandran Kandasamy, Sheela Devi Chandrakesan, Reba Kanungo
Background: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) present a considerable problem in hospitals due to a lack of effective treatment options. The primary antimicrobial agents used to treat MRSA infections are vancomycin and linezolid; however, a rising trend of minimu....
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Structural insight into Cot H3 protein inhibition targeting mucormycosis infection through computational approaches
Author details: Sugumaran Muthuraj, Nalina Viswanathan, Kavitha Thangavel, Prabhu Dhamodharan, Vidhyavathi Ramasamy
Background: This study aims to identify potential antifungal phytocompounds targeting the spore coat protein COT H3 from Rhizopus, a critical virulence factor in mucormycosis. Mucormycosis, caused by Rhizopus species, is a rapidly progressing and often fatal fungal infection with limited treatment o....
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Case Report
Unearthing Citrobacter: Rare isolation from necrotic bone
Author details: Uksim Qadri, Saleem Javaid Wani, Anjum Mir, Umaya Majid
Citrobacter are straight, facultative anaerobic gram-negative, non-sporing rods, motile by means of peritrichous flagella. They belong to family Enterobacteriaceae. The genus now consists of 13 genomospecies separable by DNA hybridisation including Citrobacter amalonaticus, Citrobacter braakii, Citr....
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Onychomycosis caused by a rare fungal pathogen: A neoscytalidium novaehollandiae case
Author details: Nidhi Mihirkumar Bhalodia, Kajal Parmar, Mihirkumar J Bhalodia, Himani Pandya, Tanuja Javadekar
This study presents a rare case of onychomycosis caused by non-dermatophytic fungi. A 43-year-old male patient visited the dermatology OPD with complaints of color change of his right fingernails after injury during farming work. The patient’s complaints did not resolve even after one month of treat....
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